Product Design
Product Design
Kriya targets common diseases where AAV gene therapy could have a transformative impact, focusing on indications with significant unmet needs, validated clinical and regulatory endpoints, and well-understood disease biology.
Leveraging our expertise in protein engineering and computational biology, our product design process combines validated biology and intelligent vector engineering with the goal of creating durable therapies for our target diseases.
Validated Biology:
Leveraging known proteins with validated biological activity accelerates gene therapy product development and minimizes risk
- Continuous expression of peptides, enzymes, and monoclonal antibodies after one-time administration of AAV gene therapy is designed to provide significant therapeutic benefit relative to frequent, recurring doses of therapeutic proteins
- Fusion proteins designed to provide enhanced therapeutic effects through greater potency and/or specificity
- Engineered ion channels designed to provide off-switch control of channel activity via selective ligand binding
Intelligent Vector Engineering:
Computationally-augmented vector design integrated with scalable manufacturing enhances performance of each gene therapy product
- Computationally-driven sequence modifications for improved manufacturability and biological activity using our proprietary SIRVETM (System for Intelligent Rational Vector Engineering) platform
- Machine learning tools for optimizing manufacturability, expression, and stability
- Generative deep learning to improve existing biologics
Durable Therapies:
Gene therapy mediated, long-term expression of a diverse range of proteins, each designed to achieve a particular therapeutic goal
- Our goal is to improve efficacy, enhance tissue specificity, and decrease patient burden relative to the frequent, recurring administration of conventional protein-based therapies
- Data from animal models supports the potential long-term durability of therapeutic effects with Kriya’s product candidates