Senior Scientist, Protein – Early Research

SUMMARY:

The best candidate will be responsible for developing new assays and testing activities relating to selection of gene therapy candidates from AAV vectors in vitro. In this role the individual will develop cell-based assays and methods for quantifying the expression and function of candidate viral vectors and their expression products. Additional assay development may include characterization of protein binding using SPR or BLI, cell imaging, and flow cytometry. This candidate will also be expected to provide direction and supervision to associate scientist in alignment of project and corporate goals.

ESSENTIAL FUNCTIONS:

• Develop Cell-based assays to quantify the expression and function of protein produced from transduced cells
• Conduct in vitro evaluation of AAV vectors to enable the selection of vectors for in vivo testing
• Develop functional assays for expressed using appropriate in vitro models
• Collaborate with other scientists to identify areas of improvement
• Evaluate new assay technologies and innovate novel assay/methodologies strategies
• Keep good lab notebook and experiment records; Authoring and review of SOPs
• Collaborate with other scientists and routinely present data
• Perform other duties as necessary

EDUCATION:

BS or equivalent with 10+ years relevant experience, MS degree or equivalent with 5+ years relevant experience, PhD or equivalent with 3+ years relevant experience

SKILLS AND REQUIREMENTS:

• Experience with ELISA, MSD, SDS-PAGE, Western blots, protein binding assays (SPR/BLI) and other protein characterization techniques
• Experience with mammalian cell culture
• Experience with oncology, CNS, and/or ocular in vitro models is preferred
• Experience with flow cytometry is preferred
• Sound understanding of statistical methods/tools for data analysis; experience with JMP, Graphpad Prism, and/or R is preferred
• Experience with training and managing of scientists
• Excellent organizational and planning skills
• Experience in working in a multi-disciplinary team environment
• Excellent written and oral communication skills
• Adaptable to change

Level and compensation will be competitive and commensurate with experience.

All interested applicants should send a cover letter and resume to [email protected]